Benefits of hyaluronic acid in treating papilla deficiencies

A natural promoter of tissue regeneration
  • Hyaluronic acid (HA), as one of the main components of the extracellular matrix, is naturally present in the human body. 1-3
  • Studies have shown that prolonged presence of HA during the healing process promotes healing by regeneration rather than reparation. 4-5
  • Besides accelerating the healing of soft tissue and bone 6-8, the bacteriostatic properties of HA also protect the wound. 9
  • Hyadent BG, a highly concentrated and cross-linked hyaluronic acid gel, is designed specifically for the application in the dental field.

How HYADENT BG works

HYADENT BG is a hyaluronic acid-based treatment solution of non- animal origin optimized for regenerative dental and periodontal applications.

  • HYADENT BG remains present throughout the various phases of the healing process due to its slow degradation pattern (several weeks). 10
  • In addition, it aids the surgical periodontal treatment after application to the root surface and soft tissue. This leads to faster wound closure, substantial pocket reduction and enhanced attachment. 11-13
  • When mixed with bone substitute material of any origin HYADENT BG forms an easily manageable putty, which may in addition lead to accelerated bone formation. 14 ,15

Features and benefits


Coordinates the post-operative inflammation process and accelates neoangiogenesis 11, 16


Stabilizes coagulum and supports tissue regeneration 11-13,16


Bacteriostatic action and reduced pathogen penetration 9

For more information consult ‘the Hyadent BG product brochure’

Hyaluronzuur Hyadent BG – Cross Linked


Videos about dental hyaluronic acid treatment

Treatment of deep mandibular recession

Professor Anton Sculean demonstrates the use of hyaluronic acid gel and connective tissue graft for the treatment of a deep mandibular recession.

Surgical treatment of infrabony defect with hyaluronic acid

Treatment of large infrabony defect using hyaluronic acid (HYADENT BG) and bone graft material by prof. Andrea Pilloni.

Clinical cases of dental hyaluronic acid treatment

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  1. Lee JY, Spicer AP. ‘Hyaluronan: a multifunctional, megadalton, stealth molecule.’ Curr Opin Cell Biol 2000;12:581–586.
  2. McDonald J, Hascall VC. ‘Hyaluronan mini review series.’ JBiol Chem 2002; 277:4575–4579.
  3. Jiang D et al. ‘Hyaluronan as an immune regulator in human diseases.’ Physiol Rev 2011;91:221–264.
  4. Longaker T et al. ‘Studies in Fetal Wound Healing: V. A prolonged presence of hyaluronic acid characterizes fetal wound healing’ Ann. Surg. 1991; April:292–296.
  5. Mast BA et al. ‘Hyaluronic Acid Modulates Proliferation, Collagen and Protein Synthesis of Cultured Fetal Fibroblast’ Matrix, 1993;13:441–446.
  6. Salbach J et al. ‘Regenerative potential of glycosaminoglycans for skin and bone.’ J Mol Med 2012;90:625–635.
  7. Muzaffer A. et al. ‘The Effect of Hyaluronic Acid-supplemented Bone Graft in Bone Healing: Experimental Study in Rabbits ’ J Biomater Appl 2006 20:209
  8. Sasaki T, Watanabe C, Bone. Vol. 16. No.1 January 1995:9-15
  9. Pirnazar P. et al. ’Bacteriostatic effects of hyaluronic acid.’ Journal of Periodontology 1999;70:370-374
  10. De Boulle K, Glogau R, Kono T, et al. ‚A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether–Crosslinked Hyaluronic Acid Dermal Fillers.’ Dermatologic Surgery 2013;39(12):1758-1766
  11. King SR, Hickerson WL, Proctor KG. Beneficial actions of exogenous hyaluronic acid on healing. Surgery 1991;109(1):76-84
  12. Fawzy ES. et al. Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial. Clin O ral Inves t 2012;16:12 2 9 -12 36
  13. Briguglio, F. et al. Treatment of infrabony periodontal defects using a resorbable biopolymer of hyaluronic acid: A randomized clinical trial. Quintessence Int 2013;44:231-240
  14. Stiller M. et al. ‘Performance of β-tricalcium phosphate granules and putty, bone grafting materials after bilateral sinus floor augmentation in humans’ Biomaterials 2014;35(10):3154-3163.
  15. Mendes RM et al. ‘Sodium hyaluronate accelerates the healing process in tooth sockets of rat’ Arch Oral Biol 2008;53:1155–1162
  16. Kessiena L. Aya et al. ‘Hyaluronan in wound healing: Rediscovering a major player.’ Wound Rep Reg 2014;22:579-593.
  17. Bevilacqua, L. et al. ‘Effectiveness of adjunctive subgingival administration of amino acids and sodium hyaluronate gel on clinical and immunological parameters in the treatment of chronic periodontitis.’ Annali di Stomatologia (Roma) 2012;3:75-81.
  18. Johannsen A. et al. ‘Local Delivery of Hyaluronan as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis’ J Periodontol 2 0 0 9 ; 8 0 :149 3 -149 7.
  19. Bertl, K. et al. ‘Hyaluronan in non-surgical and surgical periodontal therapy: a systematic review.’ J Clin Periodontol 2015;42:236-246.
  20. Shamma et al. ‚Evaluation of the effect of hyaluronic acid mixed with bisphasic calcium phosphate on bone healing around dental implants. Alexandria Dental Journal. (2017) Vol.42:104-11.
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